I use both Skype and MSN (or WLM, as it is called now). I use Skype with my closest friends and family. My dad, on the other hand, uses Skype all the time! He talks to his sister in India every morning as well as many other relatives daily.
I use MSN when I talk to fellow devs or friends that don't use Skype. It's slow and has ads... so I don't really like it a lot - but it's usefull.
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