I use Symantec Corp edition, it's got the highest detection rate in the industry, is rated 100%/ 5 of 5 etc by any group that tests it.
It's also reasonably cheap, only about $10 more per license than Nod32.
The biggest reason i use it though is it's lack of required user input.
It detects a virus, it quarantines it and only informs the user.
It updates in the background once a week or so and prompts you to attempt to clean files in quarantine if there are any.
It's a reasonably fast scanner, i wouldn't say exceptionally fast however it's realtime protection is good enough to make it's on-demand scanning somewhat redundant so i never utilise the on-demand scanner anyway.
It has snap-ins for most popular email clients, yet even if yours is not supported you'll still notice the same level of protection as if you did have a snap-in, due to the realtime protection.
Overall it simply suites my preferences the best and has the highest detection rate to boot.
Now before anyone goes on AV-Comparatives or other misc sight and quotes Norton Anti-virus, i think it best to mention that SAV is not Nortons'.
They are two entirely different scan engines, always have been and always will be. They are so different that SAV has had Heuristics for ~8 years while NAV has had it only for the last 2 or 4?
The further evidence if you don't beleive it, is teh differences in detection rates.
Even 5 years ago Symantec corp was detecting 97% odd of infections and Norton closer to 85%.
The gap has closed a little with Nortons' detecting up to 95% now heuristics have been implemented but SAV has also had a number of improvements over 5 years.
I realise that it is only available in a minimum 5 license purchase and that may be it's biggiest draw-back however; Most users don't seem to care how good an AV is as long as they have got one, so they tend to stick to AVG Free even though it's a buggy, horrid pile of crap.
That seems rather convienient, after receiving my copy i noticed it doesn't ask for a CD-key, authentification, web registration etc etc.
It's like symantec really don't care if you otherwise "Aquire" their software.