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The driver works on Windows 8 with Fireworks 64-bit, and you can scan pdfs using adobe. Photoshop 64-bit for CS4 through CS6 no longer supports TWAIN natively. Thankfully, 32-bit versions should install when you...
I found this thread to be very helpful. Thank you. I've created a video explaining how to install the driver. Epson Perfection 1650 - Windows 7 64-Bit Driver Fix - YouTube I hope this helps someone who's unfamiliar with reinstalling drivers through the device manager.