Do you use a large hosts file to block web-trash etc?
Are you using a mouse?
What Anti-virus do you use?
I will explain why I ask.
If I don't use a hosts manager the sheer size of my hosts file (over 25000 entries) causes my system to freeze up about every 15 minutes when the DNS entries are refreshed from the internet.
I had a short in my trackball wiring and it would "studder" as I moved it. It turned out it the device was being disconnected and reconnected as the wiring moved.
A/V programs are process intensive and make everything else wait; some are better than others. Try uninstalling (not just disable) and see if the problem persists. If this solves your problem then Microsoft Security Essentials (MSE) is a fairly decent free AV that you might try instead.
You might also look over this huge thread on
Freezing.