It is HIGHLY recommended to scan all files on your system!
I know this may seem redundant and such, but in your situation you need to do this.
Depends on the AV software you have and the scanning engines used as to how fast the scan takes. On my system a complete scan takes about 40 minutes over 5 partitions withing 2 500GB hard drives.
Also I noticed you have your D drive as a data drive, traditionally the D drive is reserved for the CD/DVD drives, also E if you have two CD/DVD drives. You can change the driver lettering in the Disk Management section of the System Administration section of Control Panel.
This is how mine is setup: