I love AdBlock Plus and have been using it since its inception. I found through trial and error though that the different subscriptions have a different methodology for ad blocking. Essentially, it depends on your browsing habits to find the one most suitable for you.
Also, in conjunction with Adblock Plus, I highly recommend Adblock Plus: Element Hiding Helper, as you can "surgically remove" specific elements of a page (text ads for example).
https://addons.mozilla.org/en-US/firefox/addon/4364
http://adblockplus.org/en/elemhidehelper